Michael Jackson was born in Gary, Indiana to a working-class family, the second-youngest brother of seven and the eighth of ten children of Joseph (Joe) and Katherine Jackson. Katherine, a Jehovah's Witness, raised the children in that faith, while Joe, who initially started studying with the Witnesses, eventually decided not to join. Jackson's father was a steel mill employee who often performed in an R&B band called "The Falcons" with his brother Luther. The father was a strict disciplinarian, and many of the Jackson children recall being spanked or whipped by their father for misbehaving.

Jackson showed musical talent early on and joined his brothers when they formed a group in 1964. Rolling Stone says of his early years: "First he was a prodigy" with "overwhelming musical gifts," and notes that after Jackson joined the Jackson Family vocal group at age five, "he quickly emerged as the main draw and lead singer." Even though he sang with a "child's piping voice, he danced like a grown-up hoofer and sang with the R&B/gospel inflections of Sam Cooke, James Brown, Ray Charles, and Stevie Wonder." During this period, the boys toured Indiana extensively, and after winning a major local talent show in 1966 with a rendition of The Temptations' "My Girl", led by Michael, they began playing professional gigs in Chicago, Illinois and across the mid-eastern U.S. Many of these gigs were in a string of black clubs and venues collectively known as the "chitlin' circuit," and the young kids sometimes had to open for strip tease and other adult acts in order to earn money.

The young Jackson had taken co-lead singing duties with brother Jermaine when the group's name changed from "The Jackson Brothers" to "The Jackson 5" in 1966. The group eventually auditioned for, and signed a contract with, Motown Records in 1968. They hit stardom with their first four singles, "I Want You Back", "ABC", "The Love You Save", and "I'll Be There", which charted at #1 on the Billboard Hot 100, the first time ever a group had pulled off that feat. As a solo artist, Jackson released a total of four studio albums with Motown, among them Got to Be There in 1971 and Ben in the following year. These were released as part of the Jackson 5 franchise and produced successful singles such as "Got to Be There", "Ben", and a remake of Bobby Day's "Rockin' Robin". Between 1971 and 1975, Jackson's voice "descended ever so slightly from boy soprano to his current androgynous high tenor."

The group's sales declined after 1973 and they chafed under Motown's strict refusal to allow them creative control or input. In 1976, the group signed a new contract with CBS Records (first joining the Philadelphia International division and then Epic Records). Motown Records sued the group for breach of contract.

As a result of the legal proceedings, which were complicated further by the fact that Jermaine Jackson was married to the daughter of Motown president (Berry Gordy), the Jacksons lost the rights to use the "Jackson 5" name and logo. Jermaine left the group, choosing to stay at Motown. They changed their name to "The Jacksons", featuring youngest brother Randy in Jermaine's place, and continued their successful career, touring internationally and releasing six more albums between 1976 and 1984, with Jermaine eventually re-joining in 1983, making them a sextet. From 1976 to 1984, Michael was the lead songwriter of the group, laying down such hits as "Shake Your Body (Down to the Ground)", "This Place Hotel", and "Can You Feel It". In 1978, Jackson starred as the scarecrow in The Wiz with former-label mate Diana Ross playing Dorothy. The songs for the musical were arranged by Quincy Jones, who established a partnership with Jackson during the film's production and agreed to produce his first solo album in four years.

Jackson began his charity work in 1981 with his brothers following the Triumph tour where they raised $100,000 for the Atlanta Children’s Foundation. In 1984, following his burning accident with Pepsi the drinks manufacture gave Jackson a $1.5 million out of court settlement which he donated to the Michael Jackson Burn Centre set up in his Honour. In July 1984 he donated his $5million share from the Victory tour to charity. In 1985 Jackson co-wrote with Lionel Richie the hit song "We Are the World", and sung a featured solo on the charity single. The record helped to raise money and awareness for the famine in East Africa and was one of the first instances where Jackson was seen as a humanitarian. All profits from his 1988 hit single "Man in the Mirror" went to charity.

From 1985–1990 Jackson had donated $500,000 to the United Negro College. In 1992, Jackson founded the "Heal the World Foundation" (named after his humanitarian single "Heal the World"). The charity organization brought underprivileged children to Jackson's Neverland Ranch, located outside Santa Ynez, California, to go on theme park rides which Jackson had built on the property after he purchased it in 1988. All profits from the Dangerous World Tour went to his foundation raising many millions of dollars in relief. Jacksons 1995 international #1 hit Earth Song showed a shift in his concerns to environmental issues and ends with a disclaimer asking for donations for his "Heal the World Foundation". In 1998 Jackson was nominated for a Nobel Peace Prize.

In late 2002, Jackson's Heal the World Foundation had net assets of just US$3,542 and reported $2,585 in expenses, mostly for management fees. The foundation was suspended in California since April 2002 for supposedly failing to file annual statements required of tax-exempt organizations, according to John Barrett, spokesman for the state Franchise Tax Board. The "Heal the World Foundation spread millions of dollars around the globe to help children threatened by war and disease," thanks to the efforts of Michael Jackson, but the forced closure of the Foundation leaves many of these children without aid. At the World Music Awards in 2006 Beyonce announced that Jackson had given $300 million to charity.(more than any other celebrity apart from Oprah Winfrey) and that Jackson has been actively involved with 39 charity organizations around the world.